{"id":27371,"date":"2023-11-08T10:29:39","date_gmt":"2023-11-08T10:29:39","guid":{"rendered":"https:\/\/www.certifiedcosmetics.com\/product\/nezarazene\/test-stability-a-kompatibility\/"},"modified":"2023-11-08T10:29:39","modified_gmt":"2023-11-08T09:29:39","slug":"test-stability-a-kompatibility","status":"publish","type":"product","link":"https:\/\/www.certifiedcosmetics.com\/cs\/product\/laborator\/test-stability-a-kompatibility\/","title":{"rendered":"Test stability a kompatibility"},"content":{"rendered":"<p>Testov\u00e1n\u00ed stability kosmetick\u00fdch p\u0159\u00edpravk\u016f p\u0159edstavuje s\u00e9rii hodnocen\u00ed, jejich\u017e c\u00edlem je posoudit, jak se v pr\u016fb\u011bhu \u010dasu m\u011bn\u00ed fyzik\u00e1ln\u00ed, chemick\u00e9 a mikrobiologick\u00e9 vlastnosti kosmetick\u00e9ho p\u0159\u00edpravku p\u0159i skladov\u00e1n\u00ed za r\u016fzn\u00fdch podm\u00ednek. \u00da\u010delem t\u011bchto test\u016f je zajistit, aby p\u0159\u00edpravek z\u016fstal bezpe\u010dn\u00fd, \u00fa\u010dinn\u00fd a zachoval si zam\u00fd\u0161lenou kvalitu po celou dobu sv\u00e9 trvanlivosti.  Zahrnuje simulaci environment\u00e1ln\u00edch faktor\u016f, kter\u00fdm m\u016f\u017ee b\u00fdt v\u00fdrobek vystaven b\u011bhem v\u00fdroby, distribuce a pou\u017e\u00edv\u00e1n\u00ed spot\u0159ebiteli. Zrychlen\u00e9 testov\u00e1n\u00ed stability umo\u017e\u0148uje odhadnout trvanlivost v\u00fdrobku t\u00edm, \u017ee je vystaven zv\u00fd\u0161en\u00fdm teplot\u00e1m a vlhkosti, \u010d\u00edm\u017e se simuluj\u00ed podm\u00ednky dlouhodob\u00e9ho skladov\u00e1n\u00ed. <\/p>\n<p>Testov\u00e1n\u00ed kompatibility ov\u011b\u0159uje, zda je slo\u017een\u00ed kosmetick\u00e9ho p\u0159\u00edpravku stabiln\u00ed ve spojen\u00ed s obalov\u00fdmi materi\u00e1ly, \u010d\u00edm\u017e se zajist\u00ed, \u017ee nedojde k jeho znehodnocen\u00ed ani kontaminaci.<\/p>\n<p>V n\u00e1sleduj\u00edc\u00edch p\u0159\u00edpadech je t\u0159eba prov\u00e9st nebo zopakovat testy stability:<\/p>\n<ul>\n<li>V\u00fdvoj nov\u00fdch kosmetick\u00fdch v\u00fdrobk\u016f a v\u00fdrobk\u016f pro osobn\u00ed p\u00e9\u010di,<\/li>\n<li>P\u0159epracov\u00e1n\u00ed slo\u017een\u00ed produkt\u016f ji\u017e uveden\u00fdch na trh,<\/li>\n<li>\u00daprava v\u00fdrobn\u00edch metod,<\/li>\n<li>P\u0159em\u00edst\u011bn\u00ed v\u00fdrobn\u00edho z\u00e1vodu,<\/li>\n<li>Zm\u011bna typu nebo materi\u00e1lu obalu.<\/li>\n<\/ul>\n<h2>Regula\u010dn\u00ed po\u017eadavky<\/h2>\n<p>Regula\u010dn\u00ed pokyny vyb\u00edzej\u00ed v\u00fdrobce, aby zajistili stabilitu v\u00fdrobk\u016f z hlediska jejich bezpe\u010dnosti a \u00fa\u010dinnosti, zejm\u00e9na za extr\u00e9mn\u00edch podm\u00ednek. A\u010dkoli nen\u00ed v\u017edy p\u0159\u00edsn\u011b regulov\u00e1na, kompatibilita je z\u00e1sadn\u00ed pro zaji\u0161t\u011bn\u00ed integrity a bezpe\u010dnosti v\u00fdrobk\u016f, jak zd\u016fraz\u0148uj\u00ed r\u016fzn\u00e9 oborov\u00e9 sm\u011brnice. <\/p>\n<h2>Normy a zku\u0161ebn\u00ed metody<\/h2>\n<p>B\u011b\u017en\u00e9 protokoly se \u0159\u00edd\u00ed sm\u011brnicemi ICH (Q1A) a prov\u00e1d\u011bj\u00ed se v kontrolovan\u00fdch klimatick\u00fdch komor\u00e1ch za \u00fa\u010delem posouzen\u00ed fyzik\u00e1ln\u00ed, chemick\u00e9 a funk\u010dn\u00ed stability. Neexistuje \u017e\u00e1dn\u00e1 konkr\u00e9tn\u00ed norma, av\u0161ak tyto metody obvykle zahrnuj\u00ed hodnocen\u00ed chemick\u00fdch interakc\u00ed a prov\u00e1d\u011bn\u00ed hodnocen\u00ed stability za r\u016fzn\u00fdch podm\u00ednek. <\/p>\n<h2>Zrychlen\u00e9 zkou\u0161ky stability versus zkou\u0161ky stability p\u0159i teplotn\u00edm \u0161oku<\/h2>\n<p>K posouzen\u00ed odolnosti produktu v\u016f\u010di vliv\u016fm prost\u0159ed\u00ed a k simulaci dlouhodob\u00e9ho st\u00e1rnut\u00ed za kontrolovan\u00fdch, zv\u00fd\u0161en\u00fdch podm\u00ednek za \u00fa\u010delem p\u0159edpov\u011bdi doby trvanlivosti se pou\u017e\u00edvaj\u00ed jak<strong data-start=\"151\" data-end=\"184\">zrychlen\u00e9 zkou\u0161ky stability a kompatibility<\/strong>, tak<strong data-start=\"189\" data-end=\"224\">zkou\u0161ky stability a kompatibility p\u0159i teplotn\u00edm \u0161oku<\/strong>. U obou metod se rovn\u011b\u017e posuzuje <strong data-start=\"744\" data-end=\"791\">kompatibilita mezi produktem a obalem<\/strong>, aby se zajistilo, \u017ee nedojde k \u00faniku, degradaci ani k ne\u017e\u00e1douc\u00ed interakci. <\/p>\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"891\" data-end=\"2044\">\n<thead data-start=\"891\" data-end=\"1017\">\n<tr data-start=\"891\" data-end=\"1017\">\n<th data-start=\"891\" data-end=\"926\" data-col-size=\"sm\">Funkce<\/th>\n<th data-start=\"926\" data-end=\"970\" data-col-size=\"md\">Zrychlen\u00e9 zkou\u0161ky stability<\/th>\n<th data-start=\"970\" data-end=\"1017\" data-col-size=\"md\">Zkou\u0161ky stability p\u0159i teplotn\u00edm \u0161oku<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"1146\" data-end=\"2044\">\n<tr data-start=\"1146\" data-end=\"1273\">\n<td data-start=\"1146\" data-end=\"1181\" data-col-size=\"sm\"><strong data-start=\"1148\" data-end=\"1159\">\u00da\u010del<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1181\" data-end=\"1225\">Simulace dlouhodob\u00e9ho st\u00e1rnut\u00ed a stability<\/td>\n<td data-col-size=\"md\" data-start=\"1225\" data-end=\"1273\">Simulace dlouhodob\u00e9ho st\u00e1rnut\u00ed a stability<\/td>\n<\/tr>\n<tr data-start=\"1274\" data-end=\"1403\">\n<td data-start=\"1274\" data-end=\"1309\" data-col-size=\"sm\"><strong data-start=\"1276\" data-end=\"1299\">Teplotn\u00ed profil<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1309\" data-end=\"1354\">Trvale zv\u00fd\u0161en\u00e1 teplota (nap\u0159. 4 \u00b0C \u2013 25 \u00b0C \u2013 45 \u00b0C)<\/td>\n<td data-col-size=\"md\" data-start=\"1354\" data-end=\"1403\">St\u0159\u00eddaj\u00edc\u00ed se extr\u00e9my (-15 \u00b0C \u00b1 2 \u00b0C; +20 \u00b0C \u00b1 2 \u00b0C; +45 \u00b0C \u00b1 2 \u00b0C)<\/td>\n<\/tr>\n<tr data-start=\"1404\" data-end=\"1531\">\n<td data-start=\"1404\" data-end=\"1439\" data-col-size=\"sm\"><strong data-start=\"1406\" data-end=\"1418\">Doba trv\u00e1n\u00ed<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1439\" data-end=\"1483\">95 a\u017e 105 dn\u00ed<\/td>\n<td data-col-size=\"md\" data-start=\"1483\" data-end=\"1531\">50 a\u017e 60 dn\u00ed<\/td>\n<\/tr>\n<tr data-start=\"1532\" data-end=\"1659\">\n<td data-start=\"1532\" data-end=\"1567\" data-col-size=\"sm\"><strong data-start=\"1534\" data-end=\"1551\">Simulace<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1567\" data-end=\"1611\">\u010cas a st\u00e1rnut\u00ed<\/td>\n<td data-col-size=\"md\" data-start=\"1611\" data-end=\"1659\">\u010cas a st\u00e1rnut\u00ed, p\u0159eprava nebo rychl\u00e9 vystaven\u00ed klimatick\u00fdm vliv\u016fm<\/td>\n<\/tr>\n<tr data-start=\"1660\" data-end=\"1787\">\n<td data-start=\"1660\" data-end=\"1695\" data-col-size=\"sm\"><strong data-start=\"1662\" data-end=\"1686\">Typick\u00e9 pozorovan\u00e9 vlastnosti<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1695\" data-end=\"1739\">Vzhled, z\u00e1pach, barva, pH, hustota, viskozita<\/td>\n<td data-col-size=\"md\" data-start=\"1739\" data-end=\"1787\">Vzhled, z\u00e1pach, barva, pH, hustota, viskozita<\/td>\n<\/tr>\n<tr data-start=\"1788\" data-end=\"1916\">\n<td data-start=\"1788\" data-end=\"1823\" data-col-size=\"sm\"><strong data-start=\"1790\" data-end=\"1812\">Test kompatibility<\/strong><\/td>\n<td data-col-size=\"md\" data-start=\"1823\" data-end=\"1868\">Vyhodnocuje interakci mezi v\u00fdrobkem a obalem<\/td>\n<td data-col-size=\"md\" data-start=\"1868\" data-end=\"1916\">Hodnot\u00ed interakci mezi v\u00fdrobkem a obalem<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 data-start=\"199\" data-end=\"285\">Zrychlen\u00e9 testov\u00e1n\u00ed stability: Sezn\u00e1men\u00ed s protokolem<\/h2>\n<p data-start=\"287\" data-end=\"538\">B\u011b\u017en\u00fdm postupem p\u0159i v\u00fdvoji kosmetick\u00fdch a chemick\u00fdch v\u00fdrobk\u016f je prov\u00e1d\u011bn\u00ed <strong data-start=\"364\" data-end=\"425\">test\u016f stability za kontrolovan\u00fdch teplotn\u00edch podm\u00ednek<\/strong> s c\u00edlem posoudit trvanlivost v\u00fdrobku, jeho fyzik\u00e1ln\u00ed stabilitu a odolnost slo\u017een\u00ed.<\/p>\n<h3 data-start=\"903\" data-end=\"930\">Co tento test obn\u00e1\u0161\u00ed<\/h3>\n<ul data-start=\"932\" data-end=\"1514\">\n<li data-start=\"932\" data-end=\"1104\">\n<p data-start=\"934\" data-end=\"1104\"><strong data-start=\"934\" data-end=\"960\">4 \u00b0C (chladn\u00e9 podm\u00ednky):<\/strong><br data-start=\"960\" data-end=\"963\"\/>Simuluje skladov\u00e1n\u00ed v chladni\u010dce nebo v zimn\u00edm obdob\u00ed. Pom\u00e1h\u00e1 odhalit krystalizaci, f\u00e1zovou separaci nebo nestabilitu slo\u017eek za chladn\u00fdch podm\u00ednek. <\/p>\n<\/li>\n<li data-start=\"1106\" data-end=\"1257\">\n<p data-start=\"1108\" data-end=\"1257\"><strong data-start=\"1108\" data-end=\"1137\">25 \u00b0C (pokojov\u00e1 teplota):<\/strong><br data-start=\"1137\" data-end=\"1140\"\/>Simuluje typick\u00e9 skladovac\u00ed podm\u00ednky v maloobchodn\u00edm prost\u0159ed\u00ed nebo v dom\u00e1cnosti. Zde uveden\u00e9 v\u00fdsledky nejl\u00e9pe odpov\u00eddaj\u00ed b\u011b\u017en\u00e9mu pou\u017eit\u00ed spot\u0159ebiteli. <\/p>\n<\/li>\n<li data-start=\"1259\" data-end=\"1514\">\n<p data-start=\"1261\" data-end=\"1514\"><strong data-start=\"1261\" data-end=\"1291\">45\u202f\u00b0C (zrychlen\u00e9 st\u00e1rnut\u00ed):<\/strong><br data-start=\"1291\" data-end=\"1294\"\/>Pou\u017e\u00edv\u00e1 se jako z\u00e1t\u011b\u017eov\u00e1 podm\u00ednka k simulaci \u00fa\u010dink\u016f dlouhodob\u00e9ho st\u00e1rnut\u00ed. V\u00fdrobek, kter\u00fd z\u016fstane stabiln\u00ed p\u0159i teplot\u011b 45\u202f\u00b0C po dobu 90 dn\u016f, lze pova\u017eovat za stabiln\u00ed po dobu a\u017e 1\u20132 let p\u0159i pokojov\u00e9 teplot\u011b, v z\u00e1vislosti na typu slo\u017een\u00ed. <\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1516\" data-end=\"1603\">Ka\u017ed\u00fd vzorek se sleduje v p\u0159edem stanoven\u00fdch intervalech (nap\u0159. 0, 15, 30, 60 a 90 dn\u00ed) z hlediska:<\/p>\n<ul data-start=\"1605\" data-end=\"1752\">\n<li data-start=\"1605\" data-end=\"1636\">\n<p data-start=\"1607\" data-end=\"1636\">Zm\u011bny barvy a v\u016fn\u011b<\/p>\n<\/li>\n<li data-start=\"1637\" data-end=\"1664\">\n<p data-start=\"1639\" data-end=\"1664\">zm\u011bny pH a viskozity<\/p>\n<\/li>\n<li data-start=\"1665\" data-end=\"1687\">\n<p data-start=\"1667\" data-end=\"1687\">Stabilita emulze<\/p>\n<\/li>\n<li data-start=\"1688\" data-end=\"1724\">\n<p data-start=\"1690\" data-end=\"1724\">R\u016fst mikroorganism\u016f (pokud se to t\u00fdk\u00e1)<\/p>\n<\/li>\n<li data-start=\"1725\" data-end=\"1752\">\n<p data-start=\"1727\" data-end=\"1752\">Kompatibilita obal\u016f<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"1754\" data-end=\"1782\">\u00da\u010del tohoto protokolu<\/h3>\n<p data-start=\"1784\" data-end=\"1941\">Tato metoda p\u0159edstavuje \u00fa\u010dinn\u00fd zp\u016fsob, jak posoudit, jak si produkt vede v cel\u00e9 \u0161k\u00e1le pravd\u011bpodobn\u00fdch re\u00e1ln\u00fdch i extr\u00e9mn\u00edch podm\u00ednek skladov\u00e1n\u00ed. Pom\u00e1h\u00e1: <\/p>\n<ul data-start=\"1943\" data-end=\"2175\">\n<li data-start=\"1943\" data-end=\"1982\">\n<p data-start=\"1945\" data-end=\"1982\">Odhadnout dlouhodobou stabilitu produktu<\/p>\n<\/li>\n<li data-start=\"1983\" data-end=\"2022\">\n<p data-start=\"1985\" data-end=\"2022\">V\u010das odhalit slabiny formulace<\/p>\n<\/li>\n<li data-start=\"2023\" data-end=\"2095\">\n<p data-start=\"2025\" data-end=\"2095\">Zajist\u011bte, aby obal byl za v\u0161ech okolnost\u00ed vhodn\u00fd pro dan\u00fd v\u00fdrobek<\/p>\n<\/li>\n<li data-start=\"2096\" data-end=\"2175\">\n<p data-start=\"2098\" data-end=\"2175\">Spl\u0148te regula\u010dn\u00ed po\u017eadavky t\u00fdkaj\u00edc\u00ed se registrace v\u00fdrobk\u016f nebo dokumentace CPSR<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"177\" data-end=\"264\">Zkou\u0161ky tepeln\u00e9 \u0161okov\u00e9 stability: Zaji\u0161t\u011bn\u00ed integrity v\u00fdrobku za extr\u00e9mn\u00edch podm\u00ednek<\/h2>\n<p data-start=\"266\" data-end=\"596\"><strong data-start=\"266\" data-end=\"301\">Zkou\u0161ka stability p\u0159i teplotn\u00edm \u0161oku<\/strong> je specializovanou formou zkou\u0161ky stability, kter\u00e1 slou\u017e\u00ed k posouzen\u00ed toho, jak v\u00fdrobek odol\u00e1v\u00e1 n\u00e1hl\u00fdm a extr\u00e9mn\u00edm zm\u011bn\u00e1m teploty. Tato zkou\u0161ka je obzvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e1 pro kosmetick\u00e9 v\u00fdrobky, l\u00e9\u010diva a chemick\u00e9 p\u0159\u00edpravky, kter\u00e9 mohou b\u00fdt vystaveny prom\u011bnliv\u00fdm podm\u00ednk\u00e1m p\u0159i skladov\u00e1n\u00ed nebo p\u0159eprav\u011b. <\/p>\n<h3 data-start=\"598\" data-end=\"624\">Co je to teplotn\u00ed \u0161ok?<\/h3>\n<p data-start=\"626\" data-end=\"931\">Tepeln\u00fdm \u0161okem se rozum\u00ed fyzick\u00e9 nam\u00e1h\u00e1n\u00ed a potenci\u00e1ln\u00ed po\u0161kozen\u00ed zp\u016fsoben\u00e9 rychl\u00fdm p\u0159echodem v\u00fdrobku mezi dv\u011bma teplotami, kter\u00e9 se v\u00fdrazn\u011b li\u0161\u00ed. Jedn\u00e1 se nap\u0159\u00edklad o p\u0159esun v\u00fdrobku z mraz\u00e1ku do tepl\u00e9ho prost\u0159ed\u00ed nebo z hork\u00e9ho n\u00e1kladn\u00edho vozu do chlad\u00edrny. Tyto n\u00e1hl\u00e9 zm\u011bny mohou m\u00edt vliv na:  <\/p>\n<ul data-start=\"933\" data-end=\"1065\">\n<li data-start=\"933\" data-end=\"955\">\n<p data-start=\"935\" data-end=\"955\">Stabilita emulze<\/p>\n<\/li>\n<li data-start=\"956\" data-end=\"981\">\n<p data-start=\"958\" data-end=\"981\">Viskozita a konzistence<\/p>\n<\/li>\n<li data-start=\"982\" data-end=\"1005\">\n<p data-start=\"984\" data-end=\"1005\">Barva a v\u016fn\u011b<\/p>\n<\/li>\n<li data-start=\"1006\" data-end=\"1029\">\n<p data-start=\"1008\" data-end=\"1029\">Nezporu\u0161enost obalu<\/p>\n<\/li>\n<li data-start=\"1030\" data-end=\"1065\">\n<p data-start=\"1032\" data-end=\"1065\">\u00da\u010dinnost \u00fa\u010dinn\u00e9 l\u00e1tky<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"1067\" data-end=\"1110\">Pro\u010d jsou zkou\u0161ky teplotn\u00edm \u0161okem d\u016fle\u017eit\u00e9?<\/h3>\n<p data-start=\"1112\" data-end=\"1397\">V\u00fdrobky, kter\u00e9 v podm\u00ednk\u00e1ch teplotn\u00edho \u0161oku sel\u017eou, se mohou rozpadnout, znehodnotit, za\u010d\u00edt prosakovat nebo ztratit \u00fa\u010dinnost. To m\u016f\u017ee v\u00e9st ke st\u00ed\u017enostem z\u00e1kazn\u00edk\u016f, sta\u017een\u00ed v\u00fdrobk\u016f z trhu nebo nesouladu s p\u0159edpisy. Testov\u00e1n\u00ed zaji\u0161\u0165uje, \u017ee va\u0161e slo\u017een\u00ed z\u016fstane <strong data-start=\"1340\" data-end=\"1371\">stabiln\u00ed, bezpe\u010dn\u00e9 a \u00fa\u010dinn\u00e9<\/strong> i v n\u00e1ro\u010dn\u00fdch podm\u00ednk\u00e1ch.  <\/p>\n<p data-start=\"1399\" data-end=\"1440\">Zkou\u0161ky stability p\u0159i teplotn\u00edm \u0161oku pom\u00e1haj\u00ed:<\/p>\n<ul data-start=\"1442\" data-end=\"1699\">\n<li data-start=\"1442\" data-end=\"1498\">\n<p data-start=\"1444\" data-end=\"1498\">Simulace re\u00e1ln\u00fdch p\u0159epravn\u00edch a skladovac\u00edch podm\u00ednek<\/p>\n<\/li>\n<li data-start=\"1499\" data-end=\"1529\">\n<p data-start=\"1501\" data-end=\"1529\">Ov\u011b\u0159en\u00ed \u00fadaj\u016f o dob\u011b trvanlivosti<\/p>\n<\/li>\n<li data-start=\"1530\" data-end=\"1578\">\n<p data-start=\"1532\" data-end=\"1578\">Zabra\u0148te f\u00e1zov\u00e9 separaci a krystalizaci<\/p>\n<\/li>\n<li data-start=\"1579\" data-end=\"1699\">\n<p data-start=\"1581\" data-end=\"1699\">Dodr\u017eovat regula\u010dn\u00ed po\u017eadavky (zejm\u00e9na v p\u0159\u00edpad\u011b kosmetick\u00fdch p\u0159\u00edpravk\u016f, l\u00e9\u010div a chemick\u00fdch l\u00e1tek citliv\u00fdch na teplotu)<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"903\" data-end=\"930\">V \u010dem spo\u010d\u00edv\u00e1 tento test<\/h3>\n<p data-start=\"69\" data-end=\"441\">Zkou\u0161ka se prov\u00e1d\u00ed metodou teplotn\u00edho \u0161oku, p\u0159i kter\u00e9 je vzorek v\u00fdrobku cyklicky vystavov\u00e1n extr\u00e9mn\u00edm teplot\u00e1m: -15 \u00b0C \u00b1 2 \u00b0C, +20 \u00b0C \u00b1 2 \u00b0C a +45 \u00b0C \u00b1 2 \u00b0C.<\/p>\n<p data-start=\"443\" data-end=\"585\">Tento test je podlo\u017een \u0161estit\u00fddenn\u00ed studi\u00ed kompatibility, v jej\u00edm\u017e r\u00e1mci se rovn\u011b\u017e hodnot\u00ed stabilita v\u00fdrobku v p\u016fvodn\u00edm balen\u00ed.<\/p>\n<p data-start=\"1733\" data-end=\"1829\">Zkou\u0161ka spo\u010d\u00edv\u00e1 ve vystaven\u00ed v\u00fdrobku <strong data-start=\"1785\" data-end=\"1819\">st\u0159\u00eddaj\u00edc\u00edm se teplotn\u00edm cykl\u016fm<\/strong>, jako jsou nap\u0159\u00edklad:<\/p>\n<ul data-start=\"1831\" data-end=\"1929\">\n<li data-start=\"1831\" data-end=\"1856\">\n<p data-start=\"1833\" data-end=\"1856\">  -15 \u00b0C \u00b1 2 \u00b0C, +20 \u00b0C \u00b1 2 \u00b0C a +45 \u00b0C \u00b1 2 \u00b0C, v z\u00e1vislosti na typu v\u00fdrobku a tr\u017en\u00edch norm\u00e1ch<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1931\" data-end=\"1951\">Ka\u017ed\u00fd cyklus zahrnuje:<\/p>\n<ol data-start=\"1953\" data-end=\"2172\">\n<li data-start=\"1953\" data-end=\"2036\">\n<p data-start=\"1956\" data-end=\"2036\">Um\u00edst\u011bn\u00ed v\u00fdrobku do chladic\u00ed komory na stanovenou dobu (nap\u0159. 24 hodin)<\/p>\n<\/li>\n<li data-start=\"2037\" data-end=\"2108\">\n<p data-start=\"2040\" data-end=\"2108\">Okam\u017eit\u00fd p\u0159esun do hork\u00e9 komory na stejnou dobu<\/p>\n<\/li>\n<li data-start=\"2109\" data-end=\"2172\">\n<p data-start=\"2112\" data-end=\"2172\">Tento cyklus se opakuje n\u011bkolikr\u00e1t (obvykle 3 cykly)<\/p>\n<\/li>\n<\/ol>\n<p data-start=\"2174\" data-end=\"2289\">V\u00fdrobek se po ka\u017ed\u00e9m cyklu a na konci zkou\u0161ek posuzuje z hlediska vzhledu i funk\u010dnosti. Pozorov\u00e1n\u00ed zahrnuj\u00ed: <\/p>\n<ul data-start=\"1605\" data-end=\"1752\">\n<li data-start=\"1605\" data-end=\"1636\">\n<p data-start=\"1607\" data-end=\"1636\">Zm\u011bny barvy a v\u016fn\u011b<\/p>\n<\/li>\n<li data-start=\"1637\" data-end=\"1664\">\n<p data-start=\"1639\" data-end=\"1664\">zm\u011bny pH a viskozity<\/p>\n<\/li>\n<li data-start=\"1665\" data-end=\"1687\">\n<p data-start=\"1667\" data-end=\"1687\">Stabilita emulze<\/p>\n<\/li>\n<li data-start=\"1688\" data-end=\"1724\">\n<p data-start=\"1690\" data-end=\"1724\">R\u016fst mikroorganism\u016f (pokud se to t\u00fdk\u00e1)<\/p>\n<\/li>\n<li data-start=\"1725\" data-end=\"1752\">\n<p data-start=\"1727\" data-end=\"1752\">Kompatibilita obal\u016f<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"1754\" data-end=\"1782\">\u00da\u010del tohoto protokolu<\/h3>\n<p data-start=\"1784\" data-end=\"1941\">Tato metoda p\u0159edstavuje rychl\u00fd zp\u016fsob, jak posoudit, jak si produkt vede v cel\u00e9 \u0161k\u00e1le pravd\u011bpodobn\u00fdch re\u00e1ln\u00fdch i extr\u00e9mn\u00edch podm\u00ednek skladov\u00e1n\u00ed. Pom\u00e1h\u00e1: <\/p>\n<ul data-start=\"1943\" data-end=\"2175\">\n<li data-start=\"1943\" data-end=\"1982\">\n<p data-start=\"1945\" data-end=\"1982\">Odhadnout dlouhodobou stabilitu produktu<\/p>\n<\/li>\n<li data-start=\"1983\" data-end=\"2022\">\n<p data-start=\"1985\" data-end=\"2022\">V\u010das odhalit slabiny formulace<\/p>\n<\/li>\n<li data-start=\"2023\" data-end=\"2095\">\n<p data-start=\"2025\" data-end=\"2095\">Zajist\u011bte, aby obal byl za v\u0161ech okolnost\u00ed vhodn\u00fd pro dan\u00fd v\u00fdrobek<\/p>\n<\/li>\n<li data-start=\"2096\" data-end=\"2175\">\n<p data-start=\"2098\" data-end=\"2175\">Spl\u0148te regula\u010dn\u00ed po\u017eadavky t\u00fdkaj\u00edc\u00ed se registrace v\u00fdrobk\u016f nebo dokumentace CPSR<\/p>\n<\/li>\n<\/ul>\n<h2>Odhad doby trvanlivosti<\/h2>\n<p>Odhad doby pou\u017eitelnosti kosmetick\u00e9ho p\u0159\u00edpravku prov\u00e1d\u011bn\u00fd odborn\u00edkem na bezpe\u010dnost se op\u00edr\u00e1 o kombinaci v\u00fdsledk\u016f test\u016f stability a podrobn\u00fdch informac\u00ed o p\u0159\u00edpravku poskytnut\u00fdch z\u00e1kazn\u00edkem. Odborn\u00edk posuzuje \u00fadaje, jako je slo\u017een\u00ed p\u0159\u00edpravku, obalov\u00fd materi\u00e1l, skladovac\u00ed podm\u00ednky a mikrobi\u00e1ln\u00ed stabilita, spolu s v\u00fdsledky zrychlen\u00fdch a\/nebo re\u00e1ln\u00fdch test\u016f stability. Tyto testy pom\u00e1haj\u00ed p\u0159edpov\u011bd\u011bt, jak se bude produkt chovat v pr\u016fb\u011bhu \u010dasu za norm\u00e1ln\u00edch i z\u00e1t\u011b\u017eov\u00fdch podm\u00ednek. Na z\u00e1klad\u011b tohoto hodnocen\u00ed stanov\u00ed odborn\u00edk na bezpe\u010dnost od\u016fvodn\u011bnou dobu pou\u017eitelnosti, \u010d\u00edm\u017e zajist\u00ed, \u017ee produkt z\u016fstane bezpe\u010dn\u00fd, \u00fa\u010dinn\u00fd a v souladu s regula\u010dn\u00edmi normami po celou dobu sv\u00e9ho zam\u00fd\u0161len\u00e9ho pou\u017eit\u00ed.   <\/p>\n<p>Tento odhad nen\u00ed p\u0159esn\u00fd, ale vych\u00e1z\u00ed z dostupn\u00e9 dokumentace a v\u00fdsledk\u016f laboratorn\u00edch test\u016f.  <span data-teams=\"true\">Zrychlen\u00fd test a odhad slou\u017e\u00ed jako v\u00fdchoz\u00ed bod, nenahrazuj\u00ed v\u0161ak nutnost pr\u016fb\u011b\u017en\u00e9 kontroly kvality a sledov\u00e1n\u00ed stability v souladu s GMP a regula\u010dn\u00edmi po\u017eadavky EU.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Testov\u00e1n\u00ed stability kosmetick\u00fdch p\u0159\u00edpravk\u016f p\u0159edstavuje s\u00e9rii hodnocen\u00ed, jejich\u017e c\u00edlem je posoudit, jak se v pr\u016fb\u011bhu \u010dasu m\u011bn\u00ed fyzik\u00e1ln\u00ed, chemick\u00e9 a mikrobiologick\u00e9 vlastnosti kosmetick\u00e9ho p\u0159\u00edpravku p\u0159i skladov\u00e1n\u00ed za r\u016fzn\u00fdch podm\u00ednek. \u00da\u010delem t\u011bchto test\u016f je zajistit, aby p\u0159\u00edpravek z\u016fstal bezpe\u010dn\u00fd, \u00fa\u010dinn\u00fd a zachoval si zam\u00fd\u0161lenou kvalitu po celou dobu sv\u00e9 trvanlivosti. Zahrnuje simulaci environment\u00e1ln\u00edch faktor\u016f, kter\u00fdm m\u016f\u017ee&#8230;<\/p>\n","protected":false},"featured_media":27377,"template":"","meta":[],"product_brand":[],"product_cat":[2329,3029],"product_tag":[],"class_list":["post-27371","product","type-product","status-publish","has-post-thumbnail","product_cat-laborator","product_cat-zkousky-stability","first","instock","taxable","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"bundled_by":["27633","28249","28845"],"bundle_stock_status":"instock","bundle_stock_quantity":null,"bundle_virtual":false,"bundle_layout":"","bundle_add_to_cart_form_location":"","bundle_editable_in_cart":false,"bundle_sold_individually_context":"","bundle_item_grouping":"","bundle_min_size":"","bundle_max_size":"","bundle_price":[],"bundled_items":[],"bundle_sell_ids":[],"exclude_global_add_ons":[],"addons":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.4 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Test stability a kompatibility - Certified Cosmetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.certifiedcosmetics.com\/cs\/product\/laborator\/test-stability-a-kompatibility\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Test stability a kompatibility\" \/>\n<meta property=\"og:description\" content=\"Testov\u00e1n\u00ed stability kosmetick\u00fdch p\u0159\u00edpravk\u016f p\u0159edstavuje s\u00e9rii hodnocen\u00ed, jejich\u017e c\u00edlem je posoudit, jak se v pr\u016fb\u011bhu \u010dasu m\u011bn\u00ed fyzik\u00e1ln\u00ed, chemick\u00e9 a mikrobiologick\u00e9 vlastnosti kosmetick\u00e9ho p\u0159\u00edpravku p\u0159i skladov\u00e1n\u00ed za r\u016fzn\u00fdch podm\u00ednek. \u00da\u010delem t\u011bchto test\u016f je zajistit, aby p\u0159\u00edpravek z\u016fstal bezpe\u010dn\u00fd, \u00fa\u010dinn\u00fd a zachoval si zam\u00fd\u0161lenou kvalitu po celou dobu sv\u00e9 trvanlivosti. 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